ATM truncations were also detected in many cancer types, mostly in lung, stomach, and prostate cancers.[39]PABL2 gene variation was associated with increased risk of ovarian and stomach carcinoma.[39] The POLD1 mutation was also associated with colorectal cancer and endometrial cancer predisposition.[41] More and more studies reported the common gene variations in different types of cancers. The gene discussed is POLD1; the disease is colorectal cancer.