The IL-6 and TNF-α levels in the severe (46.01 ± 12.65 and 63.39 ± 17.54 pg/mL, respectively) and the critical HFMD (75.03 ± 15.69 and 105.59 ± 17.98 pg/mL, respectively) groups were significantly higher than those in the mild (23.34 ± 8.70 and 29.75 ± 11.64 pg/mL, respectively) and control (15.40 ± 3.89 and 12.33 ± 4.81 pg/mL, respectively) groups (P < .01–.05). The gene discussed is IL6; the disease is hand, foot and mouth disease.