It has been reported that vitamin D deficiency may contribute remarkably to the loss of BMD and the occurrence of osteoporosis and fracture, especially in older and female patients.[16,17] In 1994, Morrison et al[8] first studied the potential effect of VDR genetic polymorphism on BMD and reported that allelic differences in the 3′ untranslated region of the VDR gene may participate in BMD regulation by altering messenger Ribonucleic acid levels. This evidence concerns the gene VDR and vitamin D deficiency.