MMP2 and head and neck cancer: Moreover, no significant relationships of MMP-2-1306 and -735 C/T polymorphisms were found with coronary artery disease risk [28] Whereas, other meta-analysis illustrated that the MMP-2-1306 polymorphism was significantly related to bladder cancer and head and neck cancer (HNC) risk among overall population [29–30], especially for Asian populations who were diagnosed as lung cancer [31].