In a study aiming at understanding the role of the obscurin-RhoGEF in the formation of microtentacles and in the progression of breast cancer, it was observed that a reduced LIMK activity in MCF10A cells treated with sh-obscurins correlated with an increase of tubulin detyrosination, indicative of microtubule stabilization [30]. The gene discussed is OBSCN; the disease is breast cancer.