Moreover, although both knockdown of LIMK1 and LIMK2 inhibit matrix degradation, depletion of LIMK1 specifically affects cortactin association on MT1-MMP-positive endosomes while LIMK2 knockdown specifically affects the invadopodial cortactin pool, suggesting non-redundant roles for LIMK1 and LIMK2 in matrix degradation and protein recruitment to invadopodia in breast tumor cells [58]. Here, CTTN is linked to breast neoplasm.