Consistent with our previous work with hDLL4 [7], mDLL4 significantly diminished CAIX expression in mDLL4-tumours compared to that in EV-tumours (Figure 6) as revealed by CAIX (brown) (Figure 6A) and CD34 (grey) dual staining (Figure 6B) and by its quantification (Figure 6C). This evidence concerns the gene CA9 and neoplasm.