There are growing evidence implicating Kir4.1 in various neurological diseases, i.e. mutation in KCNJ10 gene causes an autosomal recessive disorder associating early onset seizures, ataxia, mental retardation, and electrolyte imbalance [3] while a polymorphism in this gene correlates with seizure susceptibility [4]. This evidence concerns the gene KCNJ10 and Ataxia.