Whereas the mechanism by which Kir4.1 modulates glioma invasion is not elucidated, we could hypothesize that decrease in Kir4.1 expression may favor the assembly of cytoskeletal proteins, in particular actin microfilaments, in filopodia at the leading edge of motile cells causing an increase in cell invasion [13]. Here, KCNJ10 is linked to central nervous system cancer.