Whereas the mechanism by which Kir4.1 modulates glioma invasion is not elucidated, we could hypothesize that decrease in Kir4.1 expression may favor the assembly of cytoskeletal proteins, in particular actin microfilaments, in filopodia at the leading edge of motile cells causing an increase in cell invasion [13]. The gene discussed is KCNJ10; the disease is glioma.