In this regard, a sequence of chain reactions for the ischemic dysfunction of cortical GABAergic neurons may be that ischemia leads to intracellular Ca2+ increase [8] as well as PKC and CaMK-II activations [49, 50], which further upregulate the glutamate receptor-channels and glutamate release as well as downregulate voltage-gated sodium channels [36, 51–53], such that these GABAergic neurons are dysfunction. This evidence concerns the gene PRRT2 and ischemia.