Three SNPs [rs7808249 (G/A) of CROT, rs1076160 (A/G) of TSC1, rs8018360 (C/T) of RIN3] were related (P < 0.05 in at least one genetic model) to obesity, although there was no SNP significantly [P < 0.0011 (0.05/44)] associated with this condition (Table 4). This evidence concerns the gene TSC1 and obesity due to melanocortin 4 receptor deficiency.