In the case of our BMI and obesity studies, chromosomal region 1q25 was previously shown to be related to BMI [7, 8, 12], obesity [7], and body fat percentage [14], whereas FTO was previously identified as a genetic determinant of BMI [6, 12, 27], obesity [7, 28], body fat percentage [14], adiposity [29], and circulating leptin level [30]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.