Considering that the FANCD2 protein is part of the so-called Fanconi anemia pathway, inactivation of which is responsible for a debilitating disorder associated with a predisposition to various cancers, its association with CFSs provides another line of evidence to suggest that the proper replication of CFSs is crucial for the suppression of oncogenesis. Here, FANCD2 is linked to Fanconi anemia.