Besides vasculogenic mimicry, high levels of disintegrin and metalloproteinase 8 (ADAM8) are also associated with a poorer prognosis, due to its stimulating effects on tumor angiogenesis via vascular endothelial growth factor-A (VEGF-A), and on transendothelial cell migration via beta1-integrin activation [63]. Here, VEGFA is linked to neoplasm.