The first patient (KRAS-G12C-mutated adenocarcinoma) showed a mixed response with progression of hilar hepatic-node metastases (28 vs. 15 mm) and apparition of supra-centimetric latero-aortic nodes, but stability of pulmonary lesions, and was considered to have disease progression by both RECIST and irRECIST criteria (Figure 1). Here, KRAS is linked to adenocarcinoma.