Only an infection dose of above 1 × 106 caused persistent CT26 tumor regression in all replicates (15/15 with 1 × 106 vs 9/15 with 1 × 105), and a strong retardation of RenCa growth (2-fold decrease with 1 × 106 and 1 × 107 compared to 1 × 105 at 10 dpi). The gene discussed is DDX53; the disease is infection.