Matrix metalloproteinase‐2 (MMP‐2) contributes to GBM turnover via its ability to breakdown of extra‐cellular matrix (ECM) and glomerulus 41; overexpression of MMP‐2 in transgenic mice promotes renal fibrosis and generates broad spectrum of pathological and functional characteristics of human CKD 34. The gene discussed is MMP2; the disease is renal fibrosis.