RKIP is an endogenous protein that exhibits a combination of favourable effects for heart failure patients: (1) the gain/increase of cardiac contractile efficiency by the activation of Gs signalling/β1AR leading to functional recovery of the heart and (2) the protection of the heart under sympathetic stress from exaggerated β1AR downstream signalling including protection from apoptosis and pro‐arrhythmic adverse effects via β2AR activation. The gene discussed is PEBP1; the disease is heart failure.