Because increased levels of soluble CD46 (sCD46) have been observed in SLE sera21 and we have demonstrated that sCD46 abrogates the CD46‐mediated co‐induction of IL‐10 in Th1 by interfering with normal Notch signaling 10, we next assessed whether CD46 shedding may be altered in SLE T cells. This evidence concerns the gene CD46 and systemic lupus erythematosus.