To this end, we first analyzed the number of total IFN‐γ (IFN‐γ+IL‐10− andIFN‐γ+IL‐10+) or IL‐10‐positive (IFN‐γ+IL‐10+ and IFN‐γ−IL‐10+) T cells from HCs and individuals with SLE after CD3 and CD3+CD46 activation (Fig. 2A, time ‘0’). This evidence concerns the gene IL10 and systemic lupus erythematosus.