To assess if perturbation in the complement‐CD46‐driven pathways contribute to dysregulated Th1 responses observed in SLE, we activated this pathway in purified CD4+ T cells from healthy controls (HCs) and individuals with SLE (see Methods) and measured active IFN‐γ and IL‐10 secretion. The gene discussed is IL10; the disease is systemic lupus erythematosus.