Since the expression of TMEM39A mRNA was measured in PBMC, it would be also essential to establish in further studies whether the lower level of TMEM39A mRNA is not the result of different proportion of subpopulation of cells expressing TMEM39A in samples from MS patients and controls and to check the correlation between mRNA and protein level. The gene discussed is TMEM39A; the disease is myeloid sarcoma.