TMEM39A and infection: Since a large body of evidence indicates that infection with the Epstein–Barr virus has a major role in the pathogenesis of MS (Pender and Burrows, 2014), one might expect that lower expression of TMEM39A mRNA (assuming positive correlation between the levels of mRNA and protein) may be associated with higher susceptibility to infection with Epstein–Barr virus and as a consequence with higher susceptibility to multiple sclerosis.