Moreover, while the analysis of IMT has oftenbeen used in cross-sectional studies, only a few clinical trials with children haveemployed this parameter.20 TheCardiovascular Risk in Young Finns study,27 which comprised a 21 year follow-up longitudinalinvestigation, suggested that obesity indices, such as BMI, skinfold, serumlipoproteins, insulin, glucose and blood pressure, measured in youth, aresignificantly associated to increased IMT and decreased elasticity of the carotidartery in adulthood. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.