KCNH1 and cancer: Ion channels in the KCNH family (EAG, ERG and ELK) are voltage-gated potassium channels important for nervous system function, cardiac physiology, and cancer biology (Warmke and Ganetzky, 1994; Ganetzky et al., 1999; Pardo et al., 1999; Morais-Cabral and Robertson, 2015) (Figure 1—figure supplement 1).