Since these data exhibited the possibility that CXCR5− B helper T cells were also extrafollicularly involved in autoantibody production in autoimmunity models, further investigation is needed to fully describe LIP-induced PD-1+CXCR5−/dimCD4+ B-helper T cells in the pathogenesis of systemic autoimmune diseases. Here, CXCR5 is linked to Autoimmunity.