Our results for BMI and WCadjBMI, specifically associations identified near CHRNA5-CHRNA3-CHRNB4, PRNP, SLC23A2, BACH1 and NMNAT1, highlight new biological pathways and processes for future examination and may lead to a greater understanding of how oxidative stress leads to changes in obesity phenotypes and downstream cardiometabolic risk. The gene discussed is BACH1; the disease is obesity due to melanocortin 4 receptor deficiency.