Several of our novel loci have candidate genes within 500 kb of our tag variants that are highly expressed and/or active in brain tissue (BBX, KIF1B, SOX11 and EPHA3) and, like other obesity-associated genes, may be involved in previously-identified pathways linked to neuronal regulation of appetite (KIF1B, GRIN2A and SLC23A2), adipo/angiogenesis (ANGPTL3 and TNF) and glucose, lipid and energy homeostasis (CD47, STK25, STK19, RAGE, AIF1, LYPLAL1, HDLBP, ANGPTL3, DOCK7, KIF1B, PREX1 and RPS12). This evidence concerns the gene LYPLAL1 and obesity due to melanocortin 4 receptor deficiency.