Using a nominee gene attempt, we investigated whether SNPs in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) were related to the phenotype of AD in Turkish children. This evidence concerns the gene TLR2 and Alzheimer disease.