A low TTR was associated with female patients (compared to male; B=-1.32, p=0.044), a lack of knowledge of warfarin use (compared to good knowledge; B=3403, p=0.012), being uninformed about food-drug interactions (compared to informed; B=-4 807, p=0.001), chronic renal failure (compared to without chronic renal failure; B=-6569, p=0.001) and high risk scores of bleeding. The gene discussed is TTR; the disease is chronic kidney disease.