Ramucirumab (Lilly Oncology), a second-generation recombinant human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), was shown to improve OS when combined with docetaxel in the second-line setting in NSCLC (52) and is FDA approved for this indication. The gene discussed is KDR; the disease is non-small cell lung carcinoma.