MYC and hepatocellular carcinoma: The role of MYC in HB metabolism has not been studied as extensively as HCC (Cairo et al., 2008), but it is worth noting that a recent study performed global mRNA expression analysis in a somatic transgenic model of β-catenin/YAP-driven HB performed in mice with either MYC-wildtype (WT) or MYC-knockout (KO) hepatocytes.