One notable example is the regulation of MYC protein levels by HMG-CoA reductase, which has been demonstrated in the Eμ-tTA/TRE-MYC model of lymphoma, as well as the LT2-MYC model of liver cancer (Shachaf et al., 2007; Cao et al., 2011). The gene discussed is MYC; the disease is liver cancer.