The authors then demonstrated that a single enzyme, phosphoribosyl-pyrophosphate synthetase 2 (PRPS2), is responsible for increased nucleotide metabolism in MYC-driven lymphoma via a cis-regulatory element in its 5′ UTR that is activated by translation initiation factor eIF4E, which is itself hyperactivated in tumors. The gene discussed is MYC; the disease is lymphoma.