To study MYC in RCC, Shroff et al. created an inducible transgenic model of renal cell carcinoma (GGT-tTA/TRE-MYC) in which MYC is specifically overexpressed in the kidney in the absence of doxycycline (Shroff et al., 2015). This evidence concerns the gene MYC and hereditary clear cell renal cell carcinoma.