MYC and cancer: Given that cancer cell metabolism has been shown to change in metastasis initiating cells (Pascual et al., 2016), when the metastatic cells are in circulation (LeBleu et al., 2014), and depending on which organ the metastatic tumor colonizes (Dupuy et al., 2015), further studies will need to determine whether the reliance on FAO, glucose, glutamine or other metabolites present in primary MYC-overexpressing TNBC is maintained in high-burden metastases.