ACTA2 and breast cancer: On the other hand, (i) ACTA2 which has been related to increased cell motility in breast cancer and other cancer types (50, 51), (ii) POSTN, a protein secreted by cancer cells that has been described to facilitate cell motility and was recently purposed as an interesting target for prevention and treatment of breast tumor metastasis (52, 53), and (iii) VCAN, known to enhance tumorigenesis and cell mobility, invasion, and survival of breast tumors (54), are all dramatically silenced in IF1-overexpressing breast cancer cells.