ATP5IF1 and chronic myelogenous leukemia, BCR-ABL1 positive: The main of the ones described are (i) the partial downregulation of the expression of the catalytic subunit of the ATP synthase (β-F1-ATPase) (7, 15, 16), which in solid carcinomas is exerted by the specific repression of β-F1-ATPase mRNA translation (14, 17, 18) and in chronic myeloid leukemia by hypermethylation and silencing of the promoter of the ATP5B gene (19) and (ii) by the inhibition of the activity of the ATP synthase mediated by the overexpression of the ATPase inhibitory factor 1 (IF1) (20–22).