The specific inhibition of the E3 ubiquitin ligase of MG53 prevents the degradation of insulin receptor and IRS1 and indicate that MG53, acting as an E3 ubiquitin ligase, is a key negative regulator of insulin signal in skeletal muscle and that the overexpression of MG53 confers a risk of metabolic disorders (Song et al. 2013). Here, TRIM72 is linked to Other metabolic disease.