TMEM37 and viral infectious disease: In addition, at 0 hpi, which was considered as without a pathogen attack stage, no change in transcript levels of ROS related genes, PR protein genes or PAL gene were observed in TaDIR1-2-knockdown plants compared with the control plants (Figure 10 and Supplementary Figure S6), indicating that viral infection was not involved in defense response and the knockdown of TaDIR1-2 expression resulted in H2O2 as well as SA accumulation during Pst infection.