CD274 and neoplasm: However, together these findings (203, 204, 206) suggest that cell-intrinsic metabolic signaling mediated by the PD-1:PD-L1 pathway in cancer or myeloid cells of the tumor microenvironment might subsequently alter T cell immunometabolism and immune function due to nutrient competition and by generating metabolic products with detrimental effects on T cell immune function (208).