Regarding the role of GRIM-19 in cancer development, GRIM-19 expression was severely downregulated in a number of primary renal cell carcinomas (Alchanati et al., 2006), as well as in hepatocellular carcinoma (Liu et al., 2014) and oral squamous cell carcinoma (Li M. et al., 2014). The gene discussed is NDUFA13; the disease is cancer.