NDUFA13 and hereditary clear cell renal cell carcinoma: Regarding the role of GRIM-19 in cancer development, GRIM-19 expression was severely downregulated in a number of primary renal cell carcinomas (Alchanati et al., 2006), as well as in hepatocellular carcinoma (Liu et al., 2014) and oral squamous cell carcinoma (Li M. et al., 2014).