RNF112 and infection: The EAF plasmid encodes a type IV fimbria known as the bundle-forming pilus (bfp) that mediate atypical EPEC to cause persistent diarrhea although the mechanism by which it establishes infection, is still unclear (Giron et al., 1991; Donnenberg et al., 1992; Bieber et al., 1998; Knutton et al., 1999; Afset et al., 2004).