In this study, we reported for the first time honokiol induced apoptosis, G1 arrest, as well as autophagy mediated cell death in KRAS mutant lung cancer cells, and honokiol blocked KRAS mutant lung cancer cells growth by activating mitochondrial Sirt3 and suppressing HIF-1α expression (Figure 8). The gene discussed is HIF1A; the disease is lung carcinoma.