HIF1A and breast cancer: Sirt3 could mediate metabolic reprogramming in human breast cancer cells by destabilizing Hif-1α (Bell et al., 2011), The results showed that treatment of cells with honokiol increased both mRNA and protein levels of Sirt3 (Figure 7B), accompanied by a reduction of Hif-1a expression (Figure 7D), which can be destabilized by Sirt3 mediated metabolic reprogramming in human breast cancer cells (Bell et al., 2011).