VEGFA and neoplasm: Inhibition of VEGF with bevacizumab, a monoclonal antibody which binds to the VEGF ligand preventing receptor phosphorylation, has been shown to reduce angiogenesis in tumors (reducing vessel branching and growth) (Borgstrom et al., 1996), resulting in slower tumor development (Zhang et al., 2002; Holloway et al., 2006; Roland et al., 2009), reduced metastasis development (Ellis et al., 2000; Verheul et al., 2007), and improved drug delivery through vascular normalization (Tong et al., 2004; Jain, 2005).