In that context, treatment with MNA and perindopril attenuates various apparently interlinked biochemical changes closely associated with functional phenotype of endothelial dysfunction such as excessive activation of ACE, elevation of ADMA and Hcy that can all contribute to vasoprotective action of these compounds resulting in the improvement of endothelial function reported here in vivo using functional and biochemical measurements. This evidence concerns the gene ACE and endothelial dysfunction.