COMT and Alzheimer disease: It is further interesting that the genetic signals associated with AD and aggressive behavior involving the AR, BDNF, COMT, DBH, NOS1 and TPH are all complex multifunctional neurotrophic factors and/or neurotransmitters: (i) that are evolutionarily ancient; and (ii) that can be highly interactive in amplifying or reducing their role in aggressive behaviors from both neuropsychological and interdisciplinary perspectives (Narvaes and Martins de Almeida, 2014; McClam et al., 2015; Coyle et al., 2016).