NOS1 and Alzheimer disease: As for other neurotrophins and neurotransmitters such as NOS1, periodic fluctuations in COMT expression in AD may correlate with aggressive behaviors and contribute to “behavioral dys-homeostasis” via complex and highly interactive neurotrophic signaling pathways that contribute to NPS events (Perroud et al., 2010; Clelland et al., 2016).