This phenomenon is observed in various neurological disorders, such as myotonic dystrophy type 1 (DM1), fragile X-associated tremor/ataxia syndrome, C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), and polyglutamine diseases, such as Huntington’s disease (HD) and spinocerebellar ataxias (SCA). Here, C9orf72 is linked to amyotrophic lateral sclerosis.