Increased levels of Nogo-A have been reported in schizophrenia (Novak et al., 2002), multiple sclerosis (Satoh et al., 2005), temporal lobe epilepsy (Bandtlow et al., 2004) and Alzheimer’s disease (Gil et al., 2006). The gene discussed is RTN4; the disease is early-onset autosomal dominant Alzheimer disease.