From a chemical point of view, most chemical scaffolds of PARP inhibitors contain amide structure, more new chemical structures can be found in the future21, 22; From a biological point of view, although these PARP inhibitors have high PARP1/2 inhibition and anti-tumor activity; however, long-term drug administration will accompany with drug resistance, leading to tumor recurrence and metastasis23. This evidence concerns the gene PARP1 and neoplasm.