Interestingly, expression of immune regulatory molecules, including CCL3, CCL4, CCL5, TNF, IRF5, CXCL10, OAS1, TLR7, TLR8, and IL27, was highest in THP-1-derived macrophages, indicating that they are primed to mount a vigorous defense as part of the initial innate immune response to ZIKV and to elicit greater transcriptional changes in response to ZIKV infection (Figures 2E and 3B). Here, CCL5 is linked to Zika virus infectious disease.