Recently, Jiang et al. 34 has identified five novel mutations in several disease-causing genes in 298 unrelated Chinese patients with high myopia, including three heterozygous mutations (p.Lys369Met, p.Ala55OThr and p.Asp851His) inZNF644, a frame shift mutation (p.Gln67Sfs*8) in LRPAP1 and a heterozygous mutation (p.Gly413Ala) in SLC39A5. Up to now, limited mutations in the six causative genes have been confirmed, which contributed to very few high myopia cases being genetically deciphered. Here, LRPAP1 is linked to myopia.