INS and obesity due to melanocortin 4 receptor deficiency: In our 6- to 10-year follow-up (depending on the endpoints used) in unadjusted analyses, hArg was significantly and directly associated with incident obesity (BMI ≥30 kg/m2), abdominal obesity (high waist circumference), hyperglycaemia, high insulin, high-risk carotid intima-media thickness and distensibility in men, and with incident T2DM in women (Fig. 3).