IL4 and Increased total leukocyte count: The Centers for Disease Control and Prevention (CDC) reported the occurrence of leukocytosis, with predominance of neutrophils, in a patient infected by ZIKV during an outbreak in Puerto Rico in 2015 (50), and elevated levels of inflammatory mediators such as IL-1β, IL-2, IL-4, IL-6, IL-9, IL-10, IL-13, IL-17, CCL3, CCL5, CXCL10, and vascular endothelial growth factor (VEGF) were found during both acute and convalescent phases of ZIKV (51).