IFNGR1 and Zika virus infectious disease: Infection of IFN-γR−/− mice, even with higher inocula, did not induce any signs of disease manifestation, as shown by the absence of lethality (Fig. S1A) or body weight loss (Fig. S1B), indicating that type II IFN deficiency alone is not sufficient to induce disease or death after ZIKV infection.