STK25 and diabetes mellitus: The molecular mechanisms linking STK25 overexpression to changes in islet structure remain unclear at present; however, an abnormal spatial relationship between α- and β-cells is frequently observed in mouse models of diet-induced diabetes (Hinault et al. 2011, Kai et al. 2013, Trasino et al. 2015) and it is thought to contribute to β-cell dysfunction by interfering with coordination of β-cell oscillatory activity throughout the islet (Cabrera et al. 2006).