This study was 1) to investigate the effects of SAL treatment on blood pressure and cerebrovascular contractile activity independent of a functional endothelium in diabetic Goto-Kakizaki (GK) rats; 2) to investigate the effects of SAL on CaL channels of cerebral VSMCs in diabetic GK rats or when exposed to hyperglycemia condition by recording whole-cell CaL currents, assessing the expressions of CaL channel α1C-subunit and one of its downstream kinases, MLCK, at protein or mRNA levels. The gene discussed is MYLK; the disease is Hyperglycemia.