Subjects from the Alzheimer’s Disease Neuroimaging Initiative 2 with complete baseline cognitive assessment (Mini Mental State Examination, Clinical Dementia Rating [CDR] and Alzheimer’s Disease Assessment Scale–Cognitive Subscale [ADAS-cog] scores), CSF collection (amyloid-β1–42 [Aβ], tau and phosphorylated tau) and 18F-florbetapir scans were included in our cross-sectional cohort. This evidence concerns the gene MAPT and Alzheimer disease.