These proteins, associated with both AD and IR in plasma and CSF, and therefore of most interest as potential markers indicative of shared pathology, are: Ciliary neurotrophic factor receptor subunit alpha; Discoidin, CUB and LCCL domain-containing protein 2; Ephrin-B2; Leucine-rich repeat-containing protein 4B; Neuronal growth regulator 1; and SLIT and NTRK-like protein 4. The gene discussed is CNTFR; the disease is Alzheimer disease.