Six proteins were consistently significantly related to IR and AD pathology measures (Aβ, T-tau and P-tau) in both CSF and plasma: Ciliary neurotrophic factor receptor subunit alpha (CNTFR); Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2); Ephrin-B2 (ENFB2); Leucine-rich repeat-containing protein 4B (LRRC4B); Neuronal growth regulator 1 (NEGR1); and SLIT and NTRK-like protein 4 (SLITRK4). The gene discussed is EFNB2; the disease is Alzheimer disease.