MET and head and neck squamous cell carcinoma: Lastly, MET mutations that result in exon 14 skipping, deletion of the juxtamembrane domain, and loss of Casitas B-lineage lymphoma (Cbl) E3 ubiquitin-ligase recruitment, were only identified in less than 1% of HNSCC tumors, but potentially require more advanced technical methods for increased detection [47,48].