In the molecular structure of P/Q-type VGCC α1-subunit, laminin-binding domain [42] corresponds to the region that we determined the S5–S6 linker of domain III as a major focus both of the antibodies in patients with Lambert-Eaton myasthenic syndrome (LEMS, an autoimmune presynaptic disease caused mainly by antibodies against P/Q-type VGCC and partly by antibodies against synaptotagmin 1) and in the induction of LEMS animal model (active immunization model) [62]. Here, SYT1 is linked to Lambert-Eaton myasthenic syndrome.