From these above results, we suggest that the effects of acteoside and isoacteoside against Aβ 1-42-induced cognitive deficit may be related to reducing Aβ deposition, and then leading to a reversal of cortical cholinergic function, including an increase in the cortical Ach levels and a decrease in the Ach utility, by inhibiting AChE activity. Here, ACHE is linked to Cognitive impairment.