In blood vessels of healthy tissues and in tumor associated blood vessels (v), high levels of AmotL2 specific labeling was observed in nucleus and cytoplasm of endothelial cells (Figure 2, v; Figure 3C,D, v; Figure 4A–G, white arrows), pericytes (Figure S1D, arrow; Figure 4H–M, white arrows) and macrophages (Figure 4E–G, yellow arrows; Figure 4H–M, white arrowhead), identified for their morphology, localization and CD31+ expression (Figure 4E–G, yellow arrows; Figure 4H–M, arrowhead). The gene discussed is AMOTL2; the disease is neoplasm.