NR3C1 and colorectal carcinoma: Figure 6 and Figure 7 illustrate their interaction with the glucocorticoid receptor. The HSP90-FKBP52 complex co-immunoprecipitate with the glucocorticoid (GR) and the mineralocorticoid receptors and with the dynein–dynactin complex [16,55,56], indicating a retrograde movement of steroid receptors. FKBP51 is considered a negative regulator of receptor function. The glucocorticoids secretion by some CRC could be related to this pathway and have immunosuppressive functions cooperating, this way, to tumor progression [57].