AMOTL2 and colorectal carcinoma: Moreover, in the connective tissue surrounding portal tracts in healthy liver, except for a few lymphocytes, no significant population of any inflammatory cell was observed (Figure S1D), while the connective tissue of portal tracts of CRC metastasized liver tissue appeared highly infiltrated by AmotL2+ immune cells, regardless of the presence or absence of malignant cells (Figure 3A,A1 and Figure S1H).